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A number of common human foods and household ingestibles are toxic to dogs, including chocolate solids (theobromine poisoning), onion and garlic (thiosulphate, sulfoxide or disulfide poisoning), grapes and raisins, macadamia nuts, xylitol, as well as various plants and other potentially ingested materials. The nicotine in tobacco can also be dangerous. Dogs can be exposed to the substance by scavenging through garbage bins or ashtrays and eating cigars and cigarettes. Signs can be vomiting of large amounts (e.g., from eating cigar butts) or diarrhea. Some other signs are abdominal pain, loss of coordination, collapse, or death. Dogs are susceptible to theobromine poisoning, typically from ingestion of chocolate. Theobromine is toxic to dogs because, although the dog’s metabolism is capable of breaking down the chemical, the process is so slow that for some dogs even small amounts of chocolate can be fatal, especially dark chocolate.

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The genetic divergence between dogs and wolves occurred between 20,000–40,000 years ago, just before or during the Last Glacial Maximum (20,000-27,000 years ago). This timespan represents the upper time-limit for the commencement of domestication because it is the time of divergence and not the time of domestication, which occurred later. One of the most important transitions in human history was the domestication of animals, which began with the long-term association between wolves and hunter–gatherers more than 15,000 years ago. The archaeological record and genetic analysis show the remains of the Bonn–Oberkassel dog buried beside humans 14,200 years ago to be the first undisputed dog, with disputed remains occurring 36,000 years ago.

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